Author Correction: Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

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Virtual memory is conceptually simple but potentially devastating to performance. Every memory access must go through segmentation (add segment base, check limit) and then paging (look up the page table). Naively, paging alone requires two additional memory reads per access -- one for the page directory entry, one for the page table entry.